Therapy Areas: Inflammatory Diseases
New trial will study if medication holiday boosts COVID-19 vaccine protection in immunocompromised
12 November 2021 -

UK researchers plan to test how to boost COVID-19 vaccine protection in vulnerable patients whose immune systems are weakened by drugs they need for other health conditions, BBC News reported on Friday.

Currently, about 1.3 million people in the UK are on methotrexate for conditions such as rheumatoid arthritis and psoriasis. It stops flare-ups, but can make the body less able to fight infections or respond to vaccines.

In the Vroom study, the research team from the University of Nottingham will examine whether a two-week drug holiday timed to vaccination will help.

The researchers, working with other universities and hospitals, will recruit 560 methotrexate patients, and half of them will try the two-week break when they are due to have their third, or booster, COVID-19 jab.

Although the study will take one to two years to complete, scientists hope it will provide confidence for some of the most vulnerable patients at risk from COVID-19.

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