Kangpu Biopharmaceuticals, a China-based clinical stage company, announced today that it has completed a first-in-human phase one single ascending dose clinical study of KPG-818 conducted in the United States.
This randomised, double-blind, placebo-controlled study assessed the safety, tolerability and pharmacokinetics of KPG-818 in healthy male and female participants following oral administration. The company randomised a total of 40 patients to receive active drug or placebo in a double-blind fashion (eight patients in each dose cohort, six patients randomised to receive active drug and 2 subjects randomised to receive placebo). Five dose levels (2, 5, 10, 20 and 30mg) were investigated. The product is a novel small molecule modulator of the CRBN E3 ubiquitin ligase complex CRL4-CRBN.
The study results will assist the company in identifying appropriate doses of KPG-818 that can be administered in subsequent clinical trials in patients with systemic lupus erythematosus or haematological malignancies.
GSK releases decade-long data on Shingrix efficacy
GSK announces positive EAGLE-1 results for gepotidacin in gonorrhoea treatment
Boehringer Ingelheim reports strong growth in 2023 and accelerates late-stage pipeline
Charles River Laboratories launches AMAP to reduce animal testing reliance
PureTech completes enrollment in Phase 2b ELEVATE IPF trial for LYT-100
Cybin secures additional US patent for CYB003 breakthrough therapy programme
UroGen's UGN-103 IND accepted by FDA for bladder cancer treatment
Biophytis reinforces obesity IP with new patent application
MaaT Pharma reveals positive 18-month data for MaaT013 in GI-aGvHD
Fusion Antibodies plc secures contract for OptiPhage library development
Innate Pharma advances Sanofi-developed NK cell engager to Phase 2 for blood cancer patients