Policy & Regulation
Anokion Presents New Data Describing Transformative Therapeutic Approach for Treatment of Multiple Sclerosis at ECTRIMS Congress
18 September 2019 - - Swiss biotechnology company Anokion SA presented new preclinical data describing its potentially transformative therapeutic approach for multiple sclerosis at the 35th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) in Stockholm, the company said.

The poster, titled "Targeted Antigen Delivery to the Liver Induces Antigen-Specific Immune Tolerance and Modulates Pathology in Preclinical Models of Autoimmunity" (P1362), was presented by Stephan Kontos, Ph.D., co-founder and chief scientific officer of Anokion.

In MS, several autoantigens in the central nervous system are the target of inflammatory attack by self-reactive T cells that drive neurodegeneration resulting in disease pathology.

Currently available therapies for MS inhibit the function of T and B cells with the goal of reducing pathogenic T cell infiltration into the CNS.

While effective at reducing symptoms, most of these treatments carry risks of infection and other complications associated with broad immunosuppression.

By harnessing natural immune tolerance pathways in the liver, Anokion aims to address the underlying mechanism of MS with a potentially transformative therapeutic approach that induces antigen-specific tolerance to CNS autoantigens and treats neuroinflammation.

In preclinical models, the tolerogenic T cell mechanisms induced by Anokion's potent, liver-targeting technology were effective at preventing or reducing disease pathology for both MS and type 1 diabetes.

In a mouse model of MS, liver targeted MOG antigen induced pathogenic T cell anergy and deletion, resulting in protection from disease onset and therapeutic remission when tolerized during active disease.

These data were consistent with functional and mechanistic findings in a non-human primate model, supporting the translational potential in treating human autoimmune diseases, such as MS.

Anokion SA is a Swiss biotechnology company that aims to reshape people's lives by re-educating critical immune pathways in the body using durable, disease-modifying medicines for both prevalent and rare autoimmune diseases, including celiac disease, multiple sclerosis and type 1 diabetes.

Anokion's distinct approach leverages the company's immune-based platform, which targets natural pathways in the liver to restore immune tolerance and address the underlying cause of autoimmune disease.